A comparison of the blinded groups showed a nonsignificant 0.53-day (CI, ā1.25 to 0.19 days) benefit ( P = 0.075). Mean illness duration in the blinded and unblinded echinacea groups was 6.34 and 6.76 days, respectively, compared with 6.87 days in the blinded placebo group and 7.03 days in the no-pill group. A comparison of the 2 blinded groups showed a 28-point trend (95% CI, ā69 to 13 points) toward benefit for echinacea ( P = 0.089). Mean global severity was 236 and 258 for the blinded and unblinded echinacea groups, respectively 264 for the blinded placebo group and 286 for the no-pill group. Mean age was 33.7 years, 64% were female, and 88% were white. Of the 719 patients enrolled, 713 completed the protocol.
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